The hexokinase 2-dependent glucose signal transduction pathway of Saccharomyces cerevisiae
نویسندگان
چکیده
منابع مشابه
The glucose-regulated nuclear localization of hexokinase 2 in Saccharomyces cerevisiae is Mig1-dependent.
Two major mediators of glucose repression in Saccharomyces cerevisiae are the proteins Mig1 and Hxk2. The mechanism of Hxk2-dependent glucose repression pathway is not well understood, but the Mig1-dependent part of the pathway has been elucidated in great detail. Here we report that Hxk2 has a glucose-regulated nuclear localization and that Mig1, a transcriptional repressor responsible for glu...
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Cells of the yeast Saccharomyces cerevisiae have an exquisite preference for high concentrations of glucose compared to other sugars or carbon sources. The likely explanation is that glucose is the best fermentable sugar, i.e., the sugar that allows the yeast to accumulate most rapidly high levels of ethanol, which are strongly inhibitory to competing microorganisms. To accomplish rapid ferment...
متن کاملIntegration of transcriptional and posttranslational regulation in a glucose signal transduction pathway in Saccharomyces cerevisiae.
Expression of the HXT genes encoding glucose transporters in the budding yeast Saccharomyces cerevisiae is regulated by two interconnected glucose-signaling pathways: the Snf3/Rgt2-Rgt1 glucose induction pathway and the Snf1-Mig1 glucose repression pathway. The Snf3 and Rgt2 glucose sensors in the membrane generate a signal in the presence of glucose that inhibits the functions of Std1 and Mth1...
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In the presence of glucose the protein hexokinase 2 (Hxk2p), normally resident in the cytosol, is translocated to the nucleus where it impairs the activation of transcription of the glucose-repressed genes HXK1, GLK1 and SUC2, and promotes the activation of transcription of the glucose-induced genes HXK2 and HXT1. Here, we demonstrate the involvement of an heptameric motif, named the MED8 site,...
متن کاملRegulatory network connecting two glucose signal transduction pathways in Saccharomyces cerevisiae.
The yeast Saccharomyces cerevisiae senses glucose, its preferred carbon source, through multiple signal transduction pathways. In one pathway, glucose represses the expression of many genes through the Mig1 transcriptional repressor, which is regulated by the Snf1 protein kinase. In another pathway, glucose induces the expression of HXT genes encoding glucose transporters through two glucose se...
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ژورنال
عنوان ژورنال: FEMS Microbiology Reviews
سال: 2002
ISSN: 0168-6445
DOI: 10.1016/s0168-6445(01)00077-8